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. 1976 Jul 17;2(7977):126-8.
doi: 10.1016/s0140-6736(76)92849-x.

Behaviour of e antigen and antibody during chronic active liver disease. Relation to HB antigen-antibody system and prognosis

A J Vogten, W H Summerskill, G L Gitnick, S W Schalm, J L Smith, B L Murphy, J E Maynard

Behaviour of e antigen and antibody during chronic active liver disease. Relation to HB antigen-antibody system and prognosis

A J Vogten et al. Lancet. .

Abstract

Serial determinations of e antigen and e antibody were made in 20 patients with chronic active liver disease and hepatitis-B surface antigen (HBsAg) or antibody (anti-HBs). The presence of e antigen was associated with failure to clear HBsAg, produce anti-HBs, or respond to treatment with steroids. It is proposed that the presence of the e antigen is associated with impaired host immune responses to hepatitis-B virus infection and a poor prognosis.

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