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. 1966 Sep;11(3):243-54.

The preparation and properties of alexinated intermediates that react with conglutinin. I. Guinea-pig complement

P J Lachmann, R Liske

The preparation and properties of alexinated intermediates that react with conglutinin. I. Guinea-pig complement

P J Lachmann et al. Immunology. 1966 Sep.

Abstract

Evidence has been advanced confirming earlier work that conglutinin reacts solely with a determinant exposed in fixed C′3a. The reactivity is not influenced by the decay of earlier components or the activity of later ones. Heterologous sources of C′3a (rabbit and human) reacting with guinea-pig EAC′142 give conglutinable intermediates.

The stability of EAC′1423a for conglutination is much greater than for lysis. The study of decayed intermediates which still react with conglutinin suggests that the bulk of the C′3a fixed has after some time no haemolytic function. Possible explanations of this phenomenon are discussed.

The `long-term' functions of the bulk of the fixed C′3a may therefore be associated with manifestations of complement activities other than haemolysis.

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References

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