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. 1966 Oct 1;124(4):773-85.
doi: 10.1084/jem.124.4.773.

Deficiency of the sixth component of complement in rabbits with an inherited complement defect

K Rother, U Rother, H J Müller-Eberhard, J R Nilsson

Deficiency of the sixth component of complement in rabbits with an inherited complement defect

K Rother et al. J Exp Med. .

Abstract

A strain of rabbits with an inherited complement deficiency was shown to lack the sixth component of the hemolytic complement system. A method was elaborated for the partial purification of this component from normal rabbit serum. Upon injection of partially purified rabbit C'6 into C'6-deficient animals, an antibody was obtained which specifically inhibited the hemolytic activity of C'6. The data suggest that C'6-deficient serum either lacks the C'6 molecule or contains it in a chemically modified and inactive form.

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References

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