Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1966 Sep 1;124(3):431-42.
doi: 10.1084/jem.124.3.431.

Transfer of ovine experimental allergic glomerulonephritis (EAG) with serum

R A Lerner, F J Dixon

Transfer of ovine experimental allergic glomerulonephritis (EAG) with serum

R A Lerner et al. J Exp Med. .

Abstract

Serum globulin from donor sheep made nephritic by immunization with glomerular basement membrane and subsequently nephrectomized contained specific kidney-fixing antibody and was capable of inducing an immediate, although transient, glomerulonephritis when injected into unilaterally nephrectomized lambs. This nephritis was characterized by immediate proteinuria, PMN infiltration into the glomerulus, and localization of gammaG- and beta1C-globulins in a linear fashion along the recipients' glomerular capillary walls. The nephritogenic property of the serum could be absorbed in vitro with isolated sheep glomerular basement membranes.

PubMed Disclaimer

References

    1. Int Arch Allergy Appl Immunol. 1966;29(2):185-9 - PubMed
    1. Am J Ophthalmol. 1949 Dec;32(12):1687-99, illust - PubMed
    1. Proc Soc Exp Biol Med. 1962 Dec;111:568-73 - PubMed
    1. J Immunol. 1953 Nov;71(5):380-4 - PubMed
    1. J Immunol. 1956 Jun;76(6):417-27 - PubMed

Substances