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. 1977 Dec;20(12):1557-62.
doi: 10.1021/jm00222a004.

Dibenztroponeacetic and -propionic acids. Potent new antiinflammatory agents

J P Dunn, D M Green, P H Nelson, W H Rooks 2nd, A Tomolonis, K G Untch

Dibenztroponeacetic and -propionic acids. Potent new antiinflammatory agents

J P Dunn et al. J Med Chem. 1977 Dec.

Abstract

The syntheses and antiinflammatory assays of some dibenztroponeacetic and -propionic acids and derivatives are described. The most potent compound, d-2-(5H-dibenzo[a,d]cyclohepten-5-on-2-yl)propionic acid, has a potency of ca, 70 times phenylbutazone in the rat carrageenan paw assay and two to three times indomethacin in long-term animal assays. Some beta-dialkylaminoethyl esters of this compound also show high antiinflammatory activity.

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