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. 1966 Nov 4;154(3749):658-60.
doi: 10.1126/science.154.3749.658.

Allomorphic forms of bacteriophage phiX-174 replicative DNA

T F Roth, M Hayashi

Allomorphic forms of bacteriophage phiX-174 replicative DNA

T F Roth et al. Science. .

Abstract

The bacteriophage øX-174 replicative form of DNA exists in two configurations, as judged by electron microscopy and sucrose density gradient sedimentation, and on methylated albumin-coated kieselguhr column chromatography. The predominant 21S form of the DNA is a tightly twisted circle. Treatment with deoxyribonuclease causes a single scission in one of the two strands, resulting in an open circle which sediments at 16S.

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