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. 1977 Nov 25;10(2):137-54.
doi: 10.1007/BF01751807.

Formation of nucleoside 5'-phosphoramidates under potentially prebiological conditions

R Lohrmann

Formation of nucleoside 5'-phosphoramidates under potentially prebiological conditions

R Lohrmann. J Mol Evol. .

Abstract

Adenosine 5'-phosphoramidates form when solutions containing adenosine 5'-polyphosphates pnA (n greater than or equal to 3) or P1, P2-diadenosine 5'-diphosphate and amines are allowed to dry out. Mg ions catalyze these reactions. We have studied systems containing ammonia, imidazole, glycine, ethylenediamine and histamine. The yields of adenosine 5'-phosphoramidates range from 10-50% based on the nucleotide. The prebiotic significance of the reactions is discussed.

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References

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