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. 1966 Oct;92(4):1150-3.
doi: 10.1128/jb.92.4.1150-1153.1966.

Cytotoxic effects in vitro of highly purified streptolysin O on mouse macrophages cultured in a serum-free medium

R M Fuve, J E Alouf, A Delaunay, M Raynaud

Cytotoxic effects in vitro of highly purified streptolysin O on mouse macrophages cultured in a serum-free medium

R M Fuve et al. J Bacteriol. 1966 Oct.

Abstract

Fauve, Robert M. (Institut Pasteur, Garches (Hauts de Seine), France), Joseph E. Alouf, Albert Delaunay, and Marcel Raynaud. Cytotoxic effects in vitro of highly purified streptolysin O on mouse macrophages cultured in a serum-free medium. J. Bacteriol. 92:1150-1153. 1966.-After the addition of highly purified streptolysin O to mouse macrophages cultured in medium 199 containing albumin, the following cellular alterations were observed. The disappearance of the stellate shape of the cells and the formation of bleb-like vesicles extruding from the cytoplasmic membrane occurred within a few minutes. Later, massive degranulation and formation of cytoplasmic vesicles were followed by cell death.

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References

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