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. 1966 Jun 3;152(3727):1374-5.
doi: 10.1126/science.152.3727.1374.

Chloroquine: physiological basis of drug resistance in Plasmodium berghei

P B Macomber, R L O'Brien, F E Hahn

Chloroquine: physiological basis of drug resistance in Plasmodium berghei

P B Macomber et al. Science. .

Abstract

Mouse erythrocytes, parasitized by chloroquine-sensitive plasmodia, concentrate this drug in vivo to levels over twice as high as erythrocytes parasitized by chloroquine-resistant plasmodia; nonparasitized red cells accumulate little chloroquine. Selective toxicity of this drug may depend upon a special drug-concentrating mechanism of plasmodic impairment of such mechanism.

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