Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1966 Jan;182(1):131-43.
doi: 10.1113/jphysiol.1966.sp007813.

A study of the increased sensitivity of denervated and re-innervated muscle to depolarizing drugs

J Maclagan, G Vrbová

A study of the increased sensitivity of denervated and re-innervated muscle to depolarizing drugs

J Maclagan et al. J Physiol. 1966 Jan.

Abstract

1. The response of re-innervated muscles to depolarizing blocking drugs was studied.2. During the early stages of re-innervation the ;new' neuromuscular junctions are more sensitive to decamethonium and suxamethonium. The recovery from the block and the repolarization of the end-plate are markedly slowed.3. This increased sensitivity does not appear to be characteristic of all newly formed neuromuscular junctions. It was found that in new-born kittens the muscles are very insensitive to neuromuscular blocking drugs.4. It is concluded that the increased sensitivity of re-innervated muscles to depolarizing blocking drugs and the slow repolarization are due to a persistence of changes which developed during denervation.

PubMed Disclaimer

References

    1. J Physiol. 1962 Sep;163(2):324-39 - PubMed
    1. Chekh Fiziol. 1954;3(1):47-52 - PubMed
    1. J Physiol. 1960 Feb;150:399-416 - PubMed
    1. J Anat. 1944 Jan;78(Pt 1-2):15-43 - PubMed
    1. J Physiol. 1937 Jun 3;89(4):438-61 - PubMed

LinkOut - more resources