Chemical mediators of anaphylaxis (histamine, 5-HT, and SRS-A) released from horse lung and leukocytes in vitro
- PMID: 59377
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Chemical mediators of anaphylaxis (histamine, 5-HT, and SRS-A) released from horse lung and leukocytes in vitro
Res Commun Chem Pathol Pharmacol.
1976 Mar.
Abstract
Horses were sensitized to bovine plasma in Freund's complete adjuvant. Leukocytes, separated from venous blood, yielded histamine upon incubation with bovine plasma. Ioslated lung fragments incubated with bovine plasma liberated histamine and 5-HT, but not SRS-A. Pulmonary veins obtained from the same animals contracted to histamine, 5-HT and to antigen (Schultz-Dale reaction). Histamine and 5-HT probably contribute to immediate-type hypersensitivity in horses whereas the role of SRS-A is not proved.
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