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. 1966 Jul 29;153(3735):549-51.
doi: 10.1126/science.153.3735.549.

Galactose conversion to D-xylulose: an alternate route of galactose metabolism

P Cuatrecasas, S Segal

Galactose conversion to D-xylulose: an alternate route of galactose metabolism

P Cuatrecasas et al. Science. .

Abstract

Galactose dehydrogenase, a soluble enzyme of the mammalian liver, catalyzes the conversion of galactose to galactonic acid. This reaction, together with the subsequent formation of 3-ketogalactonic acid which can be decarboxylated to yield d-xylulose, is a newly discovered pathway for the metabolism of galactosee. This pathway may account for the oxidation of galactose observed in pathients with galactosemia.

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