doi: 10.1093/nar/4.11.3855.
Stereochemical model for proflavin intercalation in A-DNA
- PMID: 593890
- PMCID: PMC343205
- DOI: 10.1093/nar/4.11.3855
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Stereochemical model for proflavin intercalation in A-DNA
Nucleic Acids Res.
1977 Nov.
Free PMC article
Abstract
Linked-atom molecular modelling was employed to determine the steric and torsional requirements for intercalation of proflavine into a double-stranded region of DNA compatible with adjacent regions of cohelical A-DNA. The optimum intercalation conformation is characterized by the dihedral angles xi and psi becoming trans, with all sugars retaining the characteristics C3'-endo pucker. This extended conformation results in virtually no helical unwinding, suggesting it may be an appropriate model for an intercalative intermediary in mutagenesis by virtue of its similarity to standard helical DNA.
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