Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1966 Jun 1;123(6):1025-34.
doi: 10.1084/jem.123.6.1025.

Autoimmune disease in NZB/BL mice. 3. Induction of membranous glomerulonephritis in young mice by the transplantation of spleen cells from old mice

R C Mellors

Autoimmune disease in NZB/BL mice. 3. Induction of membranous glomerulonephritis in young mice by the transplantation of spleen cells from old mice

R C Mellors. J Exp Med. .

Abstract

The transplantation of spleen cells from old NZB/Bl mice with renal disease induced both the structural and the functional changes of membranous glomerulonephritis in young NZB/Bl mice within a few weeks and well in advance of its usual spontaneous occurrence. The development of hypergammaglobulinemia and lymphoid cell hyperplasia in the young mice indicated that immunologically competent cells, derived from either the transplant or the recipient, proliferated during this process. These experiments, together with other findings, provide further support for the view that membranous glomerulonephritis in NZB/Bl mice is produced by immunological, and probably autoimmune, mechanisms and that the renal disease is apparently almost wholly unrelated to the hemolytic process.

PubMed Disclaimer

References

    1. Ann N Y Acad Sci. 1965 Jun 30;124(1):167-77 - PubMed
    1. Aust J Exp Biol Med Sci. 1965 Jul;43:399-404 - PubMed
    1. Aust J Exp Biol Med Sci. 1963 Aug;41:315-22 - PubMed
    1. Lancet. 1961 Sep 16;2(7203):638-9 - PubMed
    1. Am J Pathol. 1957 Mar-Apr;33(2):313-29 - PubMed