doi: 10.1016/0090-6980(77)90299-4.
Synthesis of thromboxane B2 and prostaglandins by bovine gastric mucosal microsomes
- PMID: 594386
- DOI: 10.1016/0090-6980(77)90299-4
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Synthesis of thromboxane B2 and prostaglandins by bovine gastric mucosal microsomes
Prostaglandins.
1977 Nov.
Abstract
Bovine gastric mucosal microsomes synthesize prostaglandins from arachidonic acid but thromboxane B2 is the principal product. Thromboxane B2 synthesis occurs at an appreciable rate from endogenous precursor but more rapidly with added arachidonate. Nonsteroidal antiinflammatory drugs inhibited synthesis of prostaglandins and thromboxanes with the following decreasing order of potency: indomethacin, fenoprofen, acetylsalicylic acid, phenylbutazone, sulfinpyrazone, and acetaminophen.
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