Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1966 Jul 1;124(1):115-26.
doi: 10.1084/jem.124.1.115.

Crystal-induced inflammation in canine joints. II. Importance of polymorphonuclear leukocytes

P Phelps, D J McCarty Jr

Crystal-induced inflammation in canine joints. II. Importance of polymorphonuclear leukocytes

P Phelps et al. J Exp Med. .

Abstract

In an experimental model, the polymorphonuclear leukocyte was found to be necessary to the inflammation induced by crystals. This conclusion is based on (a) the invariable migration of polymorphonuclear leukocytes into the synovial fluid of canine joints injected with urate crystals, (b) the experimental suppression of the synovitis by the depletion of polymorphonuclear leukocytes in animals treated with vinblastine, (c) the dependence of the degree of suppression on the degree of leukocyte mobilization into the joint space, and (d) the restoration of the inflammatory response in a leukopenic animal by perfusion with normal blood.

PubMed Disclaimer

References

    1. Life Sci. 1964 Sep;3:1025-32 - PubMed
    1. Ann Intern Med. 1961 Mar;54:452-60 - PubMed
    1. Cancer Res. 1961 Feb;21:168-72 - PubMed
    1. J Exp Med. 1966 Jul 1;124(1):99-114 - PubMed
    1. J Exp Med. 1959 Sep 1;110:481-94 - PubMed