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. 1966 Feb 11;151(3711):696-8.
doi: 10.1126/science.151.3711.696.

Morphogenesis in Trichoderma: suppression of photoinduction by 5-fluorouracil

Morphogenesis in Trichoderma: suppression of photoinduction by 5-fluorouracil

E Galun et al. Science. .

Abstract

Sporulation in the fungus Trichoderma viride is inducible with a short light pulse. 5-Fluorouracil applied prior to photoinduction and removed thereafter suppressed sporulation without greatly aflecting growth. This compound also halved the rate of incorporation of uracil-C(14) into RNA but did not change the ratio of uridylic to cytidylic acid. The effect of 5-fluorouracil was counteracted by uracil but not by thymidine. This supports the hypothesis that 5-fluorouracil affects RNA rather than DNA.

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