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. 1976 Jul;38(1):8-12.
doi: 10.1002/1097-0142(197607)38:1<8::aid-cncr2820380103>3.0.co;2-4.

Phase II evaluation of bleomycin. A Southwest oncology Group study

C D Haas, C A Coltman Jr, J A Gottlieb, A Haut, J K Luce, R W Talley, B Samal, H E Wilson, B Hoogstraten

Phase II evaluation of bleomycin. A Southwest oncology Group study

C D Haas et al. Cancer. 1976 Jul.

Abstract

Bleomycin given intravenously (i.v.) or intramuscularly (i.m.) in twice-weekly doses of 10 mg/m2 was evaluated for efficacy and toxicity in 382 patients. Responses were observed in 11/27 Hodgkin's diseases, 10/30 lymphomas, 9/22 squamous cell cancers of ectodermal origin, 12/26 germinal cancers, and 3/8 renal adenocarcinomas. The i.m. route is less likely to casue pulmonary toxicity or hypotension than the i.v. route. Advanced age and total doses exceeding 200 mg were associated with a higher risk of lung toxicity. All responders had shown at least improvement upon receiving 200 mg; higher total doses should be used only in responding patients.

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