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. 1977 Sep;7(3):317-9.
doi: 10.1007/BF01969562.

Inhibitory effect of enkephalins on contractions of the guinea-pig ileum elicited by PGE1

Inhibitory effect of enkephalins on contractions of the guinea-pig ileum elicited by PGE1

R Jaques. Agents Actions. 1977 Sep.

Abstract

Methionine-enkephalin and leucine-enkephalin (m-enk and 1-enk) as well as D-Ala2-methionine-enkephalin amide have been shown to antagonize contractions of the isolated guinea-pig intestine elicited by PGE1, the last mentioned being the most potent of the three. The inhibitory effect of these pentapeptides is abolished by naloxone.

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