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. 1977 Dec 23;39(3):359-62.
doi: 10.1007/BF00295432.

The effect of cyclophosphamide on the centromere separation sequence in Chinese hamster spermatogonia

J R Singh, H G Miltenburger

The effect of cyclophosphamide on the centromere separation sequence in Chinese hamster spermatogonia

J R Singh et al. Hum Genet. .

Abstract

The sequence of centromere separation in spermatogonial chromosomes of untreated and cyclophosphamide-treated Chinese hamsters is described. Centromeres of chromosome 1 and 2 separated much earlier than all other chromosomes, especially 6-8. Cyclophosphamide significantly inhibits the centromere separation in all chromosome groups but does not alter the sequence of separation.

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