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. 1977 Aug;30(8):709-13.
doi: 10.1136/jcp.30.8.709.

Application of a screening test for antibody the hepatitis B core antigen

B J Cohen, Y E Cossart

Application of a screening test for antibody the hepatitis B core antigen

B J Cohen et al. J Clin Pathol. 1977 Aug.

Abstract

Hepatitis B core antigen (HBcAg) was prepared from human liver tissue and used in an immunoelectro-osmophoresis screening test to detect antibody to HBcAg (anti-HBc) in patients with evidence of liver disease and in blood donors. With the exception of two immunosuppressed HBsAg carriers, anti-HBc was found in all cases of hepatitis B infection even when HBsAg was detectable only by radioimmunoassay. Non-specific reactions were observed in 'non-B' hepatitis but, in spite of this problem, antib-HBc screening was considered a useful addition to routine tests in the clinical hepatitis laboratory.

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References

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