Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1967 Jan 13;155(3759):217-9.
doi: 10.1126/science.155.3759.217.

Tryptophan hydroxylation: measurement in pineal gland, brainstem, and carcinoid tumor

W Lovenberg, E Jequier, A Sjoerdsma

Tryptophan hydroxylation: measurement in pineal gland, brainstem, and carcinoid tumor

W Lovenberg et al. Science. .

Abstract

Development of a rapid and sensitive radioassay has permitted study of the conversion of tryptophan to 5-hydroxytryptophan in mammalian tissues. Of normal tissues examined, beef and rat pineal gland contained the highest activity. This is the first direct demonstration of tryptophan hydroxylase in this hydroxyindole-rich tissue. Rat and rabbit brainstem and human carcinoid tumor also had quantities of enzyme that could be measured easily. The reaction requires a reduced pteridine and oxygen and is inhibired by Para-Chorophenylalanine.

PubMed Disclaimer

LinkOut - more resources