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. 1967 Mar 17;155(3768):1417-9.
doi: 10.1126/science.155.3768.1417.

Chromosomal damage in human leukocytes induced by lysergic acid diethylamide

M M Cohen, M J Marinello, N Back

Chromosomal damage in human leukocytes induced by lysergic acid diethylamide

M M Cohen et al. Science. .

Abstract

Addition of lysergic acid diethylamide to cultured human leukocytes resulted in a marked increase of chromosomal abnormalities. The distribution of chromosome breaks deviated significantly from random, with an accumulation of aberrations in chromosome No. 1. Cytogenetic investigation of a patient extensively treated with this drug over a 4-year period for paranoid schizophrenia showed a similar increase in chromosomal damage.

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