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. 1967 Jul 21;157(3786):318-9.
doi: 10.1126/science.157.3786.318.

Release of slow-reacting substance of anaphylaxis in the rat: polymorphonuclear leukocyte

R P Orange, M D Valentine, K F Austen

Release of slow-reacting substance of anaphylaxis in the rat: polymorphonuclear leukocyte

R P Orange et al. Science. .

Abstract

The antigen-induced release of slow-reacting substance of anaphylaxis was studied in rats previously treated with different biological and pharmacological agents to deplete these animals of specific cellular elements. The polymorphonuclear leukocyte appears necessary as a crucial cell type for optimum release of the slow-reacting substance of anaphylaxis, whereas the mast cell and lymphocyte are not required.

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