Murine neuroblastoma clones with varying degrees of C-type virus expression

Abstract

Three tissue culture clones of neuroblastoma cells derived from the C-1300 tumor in strain A/J mice were found to contain type-C virus-specific gas antigen. None of the clones spontaneously released mouse-tropic type-C viruses although one clone, N-4, spontaneously released a xenotropic virus. Two clones, NB-2A and N-4, could be induced by treatment with 5-iododeoxyuridine and dexamethasone phosphate to produce B-tropic type-C virus, but clone N-18 failed to release either ecotropic or xenotropic virus under several different induction conditions. Karyotype analysis did not reveal specific chromosome deletions in clone N-18.