doi: 10.1042/bj1020143.
Synthesis and turnover of collagen precursors in rabbit skin
- PMID: 6030275
- PMCID: PMC1270220
- DOI: 10.1042/bj1020143
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Synthesis and turnover of collagen precursors in rabbit skin
Biochem J.
1967 Jan.
Abstract
1. The rate of synthesis of [(14)C]hydroxyproline by rabbit skin was studied in vitro and in vivo. 2. The soluble collagen fractions were shown to have a very rapid turnover. The 0.15m-sodium chloride-extractable collagen showed t((1/2)) values of 1.2hr. in vitro and 12hr. in vivo. The 0.5m-sodium chloride-extractable collagen exhibited a t((1/2)) value of 20hr. in vivo. 3. Under the conditions used it was not possible to obtain radioactive insoluble collagen in vitro. 4. A significant amount of soluble collagen is lost before it becomes insoluble. 5. These observations may help to explain why large amounts of peptide-bound hydroxyproline appear in the urine during periods of rapid collagen synthesis.
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