Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1967 Jan;102(1):65-75.
doi: 10.1042/bj1020065.

The action of aflatoxin B1 on the rat liver

J I Clifford, K R Rees

The action of aflatoxin B1 on the rat liver

J I Clifford et al. Biochem J. 1967 Jan.

Abstract

The administration of a single dose of aflatoxin B(1) to the rat (7mg./kg. body wt.) results in the slow development of a periportal necrosis. Hepatic enzymes are released into the serum in the second 24hr. of the poisoning, closely preceding the onset of the necrosis, which is followed by a rise in serum alkaline-phosphatase activity and bilirubin concentration. Aflatoxin B(1) has been detected in the nucleus of the poisoned liver cell and in vitro it has been shown to interact with DNA. The toxin inhibits the production of nuclear RNA, probably by preventing the transcription of DNA by the RNA polymerase. It is proposed that the interaction of the toxin with DNA gives rise to its inhibitory action on mitosis and its necrogenic action.

PubMed Disclaimer

References

    1. Ann N Y Acad Sci. 1960 Oct 5;89:348-60 - PubMed
    1. Biochem J. 1961 Jan;78:89-95 - PubMed
    1. Science. 1966 Mar 25;151(3717):1539-41 - PubMed
    1. Nature. 1965 Jul 24;207(995):433-4 - PubMed
    1. J Biophys Biochem Cytol. 1960 Apr;7:393-6 - PubMed

MeSH terms