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. 1967 Jan;188(1):99-105.
doi: 10.1113/jphysiol.1967.sp008126.

An upper limit to the number of sodium channels in nerve membrane?

J W Moore, T Narahashi, T I Shaw

An upper limit to the number of sodium channels in nerve membrane?

J W Moore et al. J Physiol. 1967 Jan.

Abstract

1. A small volume of artificial sea water containing 300 nM tetrodotoxin (TTX) was applied successively to seven lobster nerve trunks and the cumulative uptake of toxin investigated by bio-assay.2. Light and electron microscopy indicated that the nerve trunks had a total axonal area of 0.7 x 10(4) cm(2)/g.3. Sodium analysis gave a sodium space for the nerve trunks of 30%.4. The amount of toxin taken up by the cells in 1 g of nerve is less than 1.6 x 10(-11) moles.5. It is argued that there are probably fewer than 13 sodium channels/mu(2) axon in lobster nerve.

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References

    1. J Gen Physiol. 1965 Jul;48(6):975-96 - PubMed
    1. Science. 1964 May 29;144(3622):1100-10 - PubMed
    1. Proc R Soc Lond B Biol Sci. 1958 Feb 18;148(931):149-87 - PubMed
    1. J Gen Physiol. 1966 May;49(5):977-88 - PubMed
    1. J Gen Physiol. 1962 Jul;45:1217-38 - PubMed

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