Factors influencing the immune response. II. Effects of the physical state of the antigen and of lymphoreticular cell proliferation on the response to intraperitoneal injection of bovine serum albumin in rabbits

Abstract

The injection of Corynebacterium parvum at the same time as centrifuged bovine albumin has been shown not to have the adjuvant effect found when C. parvum is injected 6 days before. The implication of this is discussed and related to mechanisms of antibody synthesis.

Whereas particulate alum-precipitated centrifuged bovine albumin was shown to be more effective than centrifuged bovine albumin in inducing primary antibody stimulation, the reverse was true for secondary stimulation by the intraperitoneal route.