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. 1967 Jul;104(1):95-102.
doi: 10.1042/bj1040095.

Enzyme-catalysed conjugations of glutathione with unsaturated compounds

E Boyland, L F Chasseaud

Enzyme-catalysed conjugations of glutathione with unsaturated compounds

E Boyland et al. Biochem J. 1967 Jul.

Abstract

1. Rat-liver supernatant catalyses the reaction of diethyl maleate with glutathione. 2. Evidence is presented that the enzyme involved is different from the known glutathione-conjugating enzymes, glutathione S-alkyltransferase, S-aryltransferase and S-epoxidetransferase. 3. Rat-liver supernatant catalyses the reaction of a number of other alphabeta-unsaturated compounds, including aldehydes, ketones, lactones, nitriles and nitro compounds, with glutathione: separate enzymes may be responsible for these reactions.

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