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. 1967 Sep 1;157(3792):1064-5.
doi: 10.1126/science.157.3792.1064.

Herpes-type virus and chromosome marker in normal leukocytes after growth with irradiated Burkitt cells

W Henle, V Diehl, G Kohn, H Zur Hausen, G Henle

Herpes-type virus and chromosome marker in normal leukocytes after growth with irradiated Burkitt cells

W Henle et al. Science. .

Abstract

Cultured cells derived from male patients with Burkitt's lymphoma and harboring herpes-type virus particles were lethally irradiated. These irradiated cells induced normal peripheral leukocytes of female infants to grow within 2 to 4 weeks after mixed cultivation. Cells of a line free of this agent failed to stimulate growth. If either type of cell was cultured separately, it did not survive under the experimental conditions. Herpes-type viral antigen and C-group chromosomal marker previously described in cultured Burkitt cells were found in all of the female cell cultures that were obtained.

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