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. 1977 Dec;14(6):408-14.
doi: 10.1136/jmg.14.6.408.

Recurrence risks in complex inheritance with special regard to pyloric stenosis

J M Lalouel, N E Morton, C J MacLean, J Jackson

Recurrence risks in complex inheritance with special regard to pyloric stenosis

J M Lalouel et al. J Med Genet. 1977 Dec.

Abstract

A large body of data on segregating families is used to generate specific recurrence risks conditional on sex and birth order for the best-fitting model of polygenes plus maternal effect. The method is general for diseases of complex inheritance, and lies within the competence of any serious genetic clinic. The question of whether consultees demand as much specificity should be subordinate to the question of whether counsellors are justified in providing less.

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