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. 1967 Aug;104(2):435-40.
doi: 10.1042/bj1040435.

Effect of administration of the carcinogen dimethylnitrosamine on urinary 7-methylguanine

V M Craddock, P N Magee

Effect of administration of the carcinogen dimethylnitrosamine on urinary 7-methylguanine

V M Craddock et al. Biochem J. 1967 Aug.

Abstract

1. Evidence is presented for the excretion of 7-methylguanine in normal rat urine at a rate of approx. 65mug./day. Experiments with animals in which the nucleic acids had been prelabelled by treatment of the neonatal rats with [(14)C]-formate gave evidence that the methylated base originated in the nucleic acids of the rat. 2. Injection of [(14)C]dimethylnitrosamine leads to an increased excretion of 7-methylguanine, and the base becomes labelled in the methyl group. The disappearance of labelled 7-methylguanine formed in nucleic acids of rats treated with the carcinogen therefore does not take place by an N-demethylation reaction, but by liberation of the intact methylated base.

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