Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1967 Sep;104(3):914-21.
doi: 10.1042/bj1040914.

The metabolism of phenethyl bromide, styrene and styrene oxide in the rabbit and rat

S P James, D A White

The metabolism of phenethyl bromide, styrene and styrene oxide in the rabbit and rat

S P James et al. Biochem J. 1967 Sep.

Abstract

1. The chief sulphur-containing metabolite of styrene and sytrene oxide in the rabbit and rat is chromatographically identical with N-acetyl-S-(beta-hydroxyphenethyl)-l-cysteine and this compound is also formed, together with N-acetyl-S-phenethyl-l-cysteine, as a metabolite of phenethyl bromide. 2. The amounts of the phenethylmercapturic acid and its hydroxy derivative excreted in the urine of animals dosed with phenethyl bromide, styrene, styrene oxide, phenyl glycol, S-phenylethylcysteine and phenethylmercapturic acid have been determined. 3. Liver slices convert phenethylcysteine and phenethylmercapturic acid into N-acetyl-S-(beta-hydroxyphenethyl)-l-cysteine. 4. Methods for the determination by gas-liquid chromatography of mandelic acid and hippuric acid, which are metabolites of some of the compounds studied, are described.

PubMed Disclaimer

References

    1. Biochem J. 1964 Jan;90(1):127-32 - PubMed
    1. Biochem J. 1964 Mar;90(3):588-96 - PubMed
    1. Biochem J. 1966 Jan;98(1):44-56 - PubMed
    1. Biochem J. 1966 Jul;100(1):282-8 - PubMed
    1. J Chromatogr. 1967 Jan;26(1):255-8 - PubMed