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. 1976 Sep 25;2(7987):652-3.
doi: 10.1016/s0140-6736(76)92464-8.

HLA and pancreatic islet cell antibodies in diabetes

P J Morris, W J Irvine, R S Gray, L J Duncan, H Vaughan, F J McCallum, C J Campbell, J W Farquhar

HLA and pancreatic islet cell antibodies in diabetes

P J Morris et al. Lancet. .

Abstract

The frequency of HLA-B8 was significantly increased in pancreatic islet cell antibody (P.I.C.A)-positive patients (61%) compared with P.I.C.A.-negative patients (35%) and a control population (28%). This increased frequency of HLA-B8 was even more striking in diabetics in whom P.I.C.A. persisted for more than 5 years (71%). Thus the association of HLA-B8 with diabetes may be related to the presence of P.I.C.A. in these patients.

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