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. 1967 Nov;158(3804):1058-9.
doi: 10.1126/science.158.3804.1058.

Chromosome abnormality in rat leukemia induced by 7,12-dimethylbenz[a]anthracene

T Sugiyama, Y Kurita, Y Nishizuka

Chromosome abnormality in rat leukemia induced by 7,12-dimethylbenz[a]anthracene

T Sugiyama et al. Science. 1967 Nov.

Abstract

A high percentage of consistent chromosome abnormality, trisomy of the longest telocentric chromosome, was found in leukemias induced in rats of the Long-Evans strain by pulse doses of 7,12-dimethylbenz[a]anthracene. Cells with this abnormality were large, immature, and mononuclear and tended toward erythroblastic maturation.

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