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. 1967 Dec 15;158(3807):1479-80.
doi: 10.1126/science.158.3807.1479.

Pemoline levels in brain: enhancement by dimethyl sulfoxide

J J Brink, D G Stein

Pemoline levels in brain: enhancement by dimethyl sulfoxide

J J Brink et al. Science. .

Abstract

Pemoline-C(14) dissolved in dimethyl sulfoxide and injected intraperitoneally into rats was found in larger amounts in the brain than was a similar dose given in 0.3 percent tragacanth suspension. This appeared to be related to a partial breakdown of the blood-brain barrier in vivo by the dimethyl sulfoxide.

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