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Case Reports
. 1977 Dec;52(12):937-42.
doi: 10.1136/adc.52.12.937.

Mannosidosis. Clinical and biochemical study

P J Milla, I E Black, A D Patrick, K Hugh-Jones, V Oberholzer
Case Reports

Mannosidosis. Clinical and biochemical study

P J Milla et al. Arch Dis Child. 1977 Dec.

Abstract

The clinical, radiological, and biochemical features of 2 male children with mannosidosis are described. Superficially they appeared to suffer from Hurler's syndrome, but the facies, eye signs, radiological and cytological features were atypical. Excess urinary oligosaccharides were found by thin-layer chromatography. The diagnosis was confirmed by determining the acidic alpha-mannosidase activity of leucocytes and cultured skin fibroblasts. Prenatal diagnosis is possible from cultured amniotic cells.

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References

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