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. 1967 Oct;35(1):247-55.
doi: 10.1083/jcb.35.1.247.

DNA-dependent formation of the synaptinemal complex at meiotic prophase

T F Roth, M Ito

DNA-dependent formation of the synaptinemal complex at meiotic prophase

T F Roth et al. J Cell Biol. 1967 Oct.

Abstract

EVALAUTION OF MICROSPOROCYTES CULTURED DURING DISCRETE PERIODS OF MEIOTIC PROPHASE IN THE PRESENCE OF DEOXYADENOSINE, AN INHIBITOR OF DNA SYNTHESIS, INDICATE THAT: (1) late leptonema or early zygonema DNA synthesis is required to initiate the formation of the synaptinemal complex; (2) DNA synthesized during late zygonema is necessary for the disjunction of the paired homologs at diplonema; and (3) DNA synthesis in pachynema is a requisite for normal anaphase II separation of sister chromatids.

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