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. 1977 Dec;52(12):965-7.
doi: 10.1136/adc.52.12.965.

Influence of the central nervous system on fetal lung development. Experimental study

J S Wigglesworth, R M Winston, K Bartlett

Influence of the central nervous system on fetal lung development. Experimental study

J S Wigglesworth et al. Arch Dis Child. 1977 Dec.

Abstract

Upper cervical cord injury was produced in fetal rabbits at 22-26 days' gestation. In 11 setuses with severe cord injury delivered at 28-29 days' gestation there was a median reduction in lung weight (expressed as a proportion of body weight) of 43% and a median reduction in estimated total lung DNA of 16% in comparison with paired operated littermates with intact cords. The hypoplastic lungs showed collapse on histology; if cord damage had been inflicted before 24 days' gestation there was retarded maturation. We conclude that the central nervous system plays a vital role in fetal lung growth and maturation, probably by maintenance of fetal respiratory movements.

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References

    1. J Anat. 1977 Jul;123(Pt 3):649-60 - PubMed
    1. J Clin Pathol Suppl (R Coll Pathol). 1976;10:27-30 - PubMed
    1. Arch Intern Med. 1970 Aug;126(2):311-29 - PubMed
    1. Arch Dis Child. 1973 Sep;48(9):709-13 - PubMed
    1. Lab Invest. 1973 Mar;28(3):352-60 - PubMed

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