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. 1977 Dec;24(6):601-4.
doi: 10.1507/endocrj1954.24.601.

Stimulation of immunoreactive somatostatin release from hypothalamic synaptosomes by high (K+) and dopamine

I Wakabayashi, Y Miyazawa, M Kanda, N Miki, R Demura, H Demura, K Shizume
Free article

Stimulation of immunoreactive somatostatin release from hypothalamic synaptosomes by high (K+) and dopamine

I Wakabayashi et al. Endocrinol Jpn. 1977 Dec.
Free article

Abstract

Effects of high (K+) and dopamine on the release of immunoreactive somatostatin from isolated hypothalamic synaptosomes were studied in rats. High (K+) (60 mM) and dopamine (10(-6) M) in the incubation media stimulated the release of immunoreactive somatostatin and the former effect was completely abolished by the removal of Ca++ from the media. These suggest that hypothalamic somatostatinergic synaptosomes preserved at least one of the important basic properties of secretory cells. Although it is of interest to note that dopamine stimulated the release of somatostatin. Its physiological significance awaits further studies.

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