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. 1984 Dec;83(4):899-902.
doi: 10.1111/j.1476-5381.1984.tb16529.x.

Inhibition of allergic and non-allergic histamine secretion from rat peritoneal mast cells by calcium antagonists

N Chand, W Diamantis, J Pillar, R D Sofia

Inhibition of allergic and non-allergic histamine secretion from rat peritoneal mast cells by calcium antagonists

N Chand et al. Br J Pharmacol. 1984 Dec.

Abstract

Bepridil, TMB-8 (8-(diethylamino)octyl 3,4,5-trimethoxybenzoate hydrochloride), diltiazem, verapamil and nifedipine exerted concentration-dependent inhibition of antigen and calcium ionophore A23187-induced histamine release from rat peritoneal mast cells. The inhibitory effects of verapamil and bepridil against calcium ionophore A23187-induced histamine secretion were antagonized by increased Ca2+ concentrations in the extracellular medium. These observations suggest that both agents act by interfering with the influx of Ca2+ into the mast cells. The inhibitory activities of five different Ca2+ channel blockers on allergic and non-allergic histamine secretion from rat peritoneal mast cells varied considerably depending upon the nature of the secretagogue as well as concentration and type of Ca2+-antagonist examined.

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