Comparative Study
doi: 10.1016/0304-3940(84)90408-7.
Rat sensory ganglia incorporate radiolabelled amino acids into substance K (neurokinin alpha) in vitro
- PMID: 6084208
- DOI: 10.1016/0304-3940(84)90408-7
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Comparative Study
Rat sensory ganglia incorporate radiolabelled amino acids into substance K (neurokinin alpha) in vitro
Neurosci Lett.
.
Abstract
Isolated rat dorsal root ganglia incorporated [3H]valine, [3H]serine, [3H]phenylalanine and [3H]histidine into a peptide which co-eluted with authentic substance K (neurokinin alpha) on reverse-phase HPLC. Confirmation of the identity of this peptide with substance K was obtained by demonstrating that the sulphoxide derivative of the peptide co-eluted with substance K sulphoxide. Substance P and substance K were synthesised in the ratio 2.6:1. The implications of these results for the co-synthesis of substance P and substance K in sensory neurones are discussed.
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