Investigation of the antigenic structure of rabies virus glycoprotein by monoclonal antibodies

Abstract

Comparative antigenic analysis of glycoprotein variants of ERA and CVS-11 strains of rabies virus by monoclonal antibodies has permitted the delineation of three antigenic sites on the glycoprotein common to both strains. Two additional antigenic sites have been delineated on the ERA strain virus glycoprotein. The topologic relationship of these antigenic sites has been investigated.