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. 1984 Dec;4(12):2921-4.
doi: 10.1128/mcb.4.12.2921-2924.1984.

Transcription of the mouse dihydrofolate reductase gene proceeds unabated through seven polyadenylation sites and terminates near a region of repeated DNA

E G Frayne, E J Leys, G F Crouse, A G Hook, R E Kellems

Transcription of the mouse dihydrofolate reductase gene proceeds unabated through seven polyadenylation sites and terminates near a region of repeated DNA

E G Frayne et al. Mol Cell Biol. 1984 Dec.

Abstract

We observed equimolar transcription throughout the 35-kilobase mouse dihydrofolate reductase structural gene. Transcription termination occurred within a discrete region (900 base pairs) located 1 kilobase beyond the last of seven functional polyadenylation sites and near a repetitive DNA sequence element. The results imply that a distinct genetic signal may be associated with the process of transcription termination.

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