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Review
. 1984 Sep;2(3):177-84.
doi: 10.1016/0264-410x(84)90081-1.

New poliovirus vaccines: a molecular approach

J W Almond, G Stanway, A J Cann, G D Westrop, D M Evans, M Ferguson, P D Minor, M Spitz, G C Schild
Review

New poliovirus vaccines: a molecular approach

J W Almond et al. Vaccine. 1984 Sep.

Abstract

This article summarizes recent work on the determinants of antigenicity in poliovirus type 3 and reports on experiments in progress aimed at understanding the molecular basis of attenuation in Sabin's type 3 vaccines. Ways in which this new information might be used to produce alternative, safe, inexpensive, multivalent vaccines against polio and other enteroviruses are discussed.

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