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. 1984 Sep;12(2):85-9.
doi: 10.1016/0160-5402(84)90025-1.

A simple system for the investigation of protein binding effects on the renal handling of drugs in an isolated perfused rat kidney preparation

S D Hall, M Rowland

A simple system for the investigation of protein binding effects on the renal handling of drugs in an isolated perfused rat kidney preparation

S D Hall et al. J Pharmacol Methods. 1984 Sep.

Abstract

An isolated perfused rat kidney preparation was developed that allowed drug-protein binding in the perfusate to be varied while maintaining renal function. When applied to digitoxin and frusemide, two drugs highly bound to bovine serum albumin, the fraction of drug unbound could be continuously varied over approximately a 30-fold range.

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