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. 1977 Aug;33(2):209-15.

In vitro inhibition of human peripheral blood lymphocyte transformation by an extract of Pseudomonas putida

C V Hunt, W Khan, G Friedman, J C Houck

In vitro inhibition of human peripheral blood lymphocyte transformation by an extract of Pseudomonas putida

C V Hunt et al. Immunology. 1977 Aug.

Abstract

An extract prepared from a psychrophilic strain of Pseudomonas putida was found to cause a dose-dependent inhibition of [H3]TdR incorporation into human peripheral blood lymphocytes stimulated with PHA, ConA, PWM, or in a mixed lymphocyte reaction. The inhibition was found not to be the result of cytotoxicity, culture medium depletion of a component necessary for lymphocyte transformation, or interference with label uptake by blast lymphocytes. The extract was most effective when added prior to 48 h of mitogen stimulation. The inhibitory material was photeolytic enzyme degradable, heat-stable and non-dialyzable.

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