[Pathology and histogenesis of gastric scirrhous carcinoma]

Abstract

Gastric scirrhous carcinoma can be tentatively defined as the following. Histologically, poorly differentiated adenocarcinoma, scirrhous type, according to histological classification by Japanese Research Society for Gastric Cancer. Grossly, Borrmann IV type (diffusely infiltrating without ulceration or mass formation). Extensive infiltration of the stomach. Gastric scirrhous cancers were classified as follows. Pyloric stenotic type (6 cases). Cancers were located at the distal pyloric portion, causing stenosis, and considered to originate from the pyloric gland. IIc-erosive type (6 cases). Cancers were located about at the border between pyloric and fundic areas, and considered to arise from the intermediate (or transitional) zone. Rugal type (or Linitis plastica type) (9 cases). Cancers were located at the gastric corpus, causing giant rugae in the fundic region, and considered to originate from the fundic gland. Gastric scirrhous cancers must start at the gastric mucosa as intramucosal cancers, whose histology shows adenocarcinoma mucocellular (signet-ring cell carcinoma). Signet-ring shaped cells in adenocarcinoma mucocellulare disclosed at least three types as follows.