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. 1984 Aug;34(8):1117-9.
doi: 10.1212/wnl.34.8.1117.

Theiler's virus antigen detected in mouse spinal cord 2 1/2 years after infection

Theiler's virus antigen detected in mouse spinal cord 2 1/2 years after infection

H L Lipton et al. Neurology. 1984 Aug.

Abstract

Spinal cord sections from mice injected with Theiler's murine encephalomyelitis virus (TMEV) and surviving for 1 year and longer after infection were stained for virus antigen by two immunohistochemical techniques. Virus antigen was detected from 1 to 2 1/2 years after infection, a time when no virus was recovered at an assay sensitivity of 50 plaque-forming units per gram of tissue. The implication this has regarding the detection of a virus in MS is discussed.

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